Although there was no evidence proving the direct in vivo involvement of mTIGIT alone in controlling tumor metastases in these models, there was a synergistic effect of mCD96 and mTIGIT since blocking of mCD96 with anti-mCD96 mAb in TIGIT−/− animals caused a higher degree of reduction of the numbers of tumor metastases in comparison with anti-mCD96 mAb administration in WT animals (61). This evidence concerns the gene TIGIT and neoplasm.