IFNA1 and type 1 diabetes mellitus: Experiments based on depletion of cell subsets indicated that B-1a cells, neutrophils, and IFN-α-producing pDCs are required for the initiation of the diabetogenic T cell response and T1D development (68), suggesting that an innate immune cell dialog that starts in the pancreas of young NOD mice can lead to the initiation of T1D.