TLR4 and asthma: As shown in Figure 2, in mouse models where sensitization is performed with alum adjuvant adsorption of TLR4 agonists to alum prevent type-2 sensitization (54) through TLR4- and/or MyD88-dependent but TRIF-independent mechanism (7, 8), indicating that TLR4 signaling during allergic sensitization dampens development of asthma-like responses.