IFNG and asthma: The therapeutic effects of TLR7 agonist have been evaluated by Nencini et al. that reported that conjugation of OH-modified adenine, a novel TLR7 ligand, with both Der p 2 (Der p 2-Conj) and OVA (OVA-Conj) diminished Th2-mediated airway inflammation in an IL-10 and IFN-γ-dependent manner (110), although the exact mechanisms by which TLR7 agonists forestall asthma development are still elusive.