The pro-allergic effect of TLR2 was emphasized in chronic fungal asthma model induced by i.p. and s.c. injection of soluble A. fumigatus antigens dissolved in incomplete Freund’s adjuvant where Tlr2−/− C57BL/6 mice showed attenuation of airway hyperresponsiveness, decreased Th2-type cytokines, and suppression of chemokine production when compared to WT mice (81). Here, TLR2 is linked to asthma.