For example, whereas the glaucoma-associated E50K mutation in optineurin enhances its interaction with TBK1 resulting in impacts on the oligomeric state of optineurin, the ALS-associated E696K mutation of TBK1 abolishes its interaction with optineurin leading to a failure of mitochondrial translocation (20, 52). This evidence concerns the gene TBK1 and amyotrophic lateral sclerosis.