Moreover, autophagy is required for the ability of Treg cells to suppress antitumor responses in vivo as illustrated by an impaired tumor growth of MC38 colon adenocarcinoma cells in Atg7fl/fl:Foxp3Cre mice associated with a loss of Treg cells and an increased expression of IFN-γ from T cells at the tumor site. Here, IFNG is linked to neoplasm.