↑ Sepsis (vs normal in whole blood, CD8, and monocytes)↑ Tuberculosis (vs normal)↑ Leishmaniasis (vs normal)↑ Lyme disease at acute phase of infection (vs normal)↑ Interstitial cystitis (ulcer vs normal)↑ Psoriasis (at lesional skin vs normal at normal skin)↑ Burn (vs control at early stage and middle stage)↓ Francisella tularensis novicida (vs uninfect)↓ Mycobacterium tuberculosis (vs none in macrophage at 48 h). Here, CD8A is linked to Lyme disease.