Using the 1000 Genomes Project data (36), we determined haplotype frequencies for the IRF5 locus (Figure 1A) for AFRs, Latino/Hispanics, EASs, EURs, and SASs Most of the IRF5 variants associated with SLE are in a high degree of LD (Figure 1B). The gene discussed is IRF5; the disease is systemic lupus erythematosus.