The latter include TLR-9, cyclic GMP-AMP synthase, DNA-dependent activator of IFN-regulatory factors, absent in melanoma 2, STING, gamma-interferon inducible protein-16, nucleotide-binding domain leucine-rich repeat containing protein family pyrin domain containing 3, DEAD/H-box helicase 41, and meiotic recombination 11 protein [summarized in Ref. The gene discussed is STING1; the disease is melanoma.