In contrast, in the tumor AOM/DSS model, less macrophages were found in NoxO1−/−-deficient tumors, as analyzed by conventional immunohistochemistry (Figure S4A in Supplementary Material) and a costaining of F4/80 (Adgre1) and the Noxes on mRNA level (Figure S4B in Supplementary Material). The gene discussed is ADGRE1; the disease is neoplasm.