Studies in animal models have suggested that reduced PI3K/AKT/mTOR/S6K signaling (hypoactivation) can lead to immune deficiency, whereas uncontrolled PI3K/AKT/mTOR/S6K signaling (hyperactivation) is associated with autoimmunity and hematological malignancies (12). The gene discussed is PIK3CB; the disease is Autoimmunity.