In this context, the effect of ST2 deficiency in staphylococcal arthritis was evident since the first day after bacteria injection, inducing articular hyperalgesia, edema and a focal collection of immune cells that secret proinflammatory mediators such as TNF-α and IL-1β, which in turn contribute to the knee joint lesion, abscess and function loss (28). The gene discussed is TNF; the disease is abscess.