IL-33 is protective during acute phase of sepsis (19), keratitis caused by Pseudomonas aeruginosa (20) or Staphylococcus aureus wound infection (21) and in parasitic diseases with Trichuris muris (22), Schistosoma mansoni (23), or Toxoplasma gondii (24), whereas it is deleterious during cutaneous and visceral leishmaniasis (10, 25, 26). The gene discussed is IL33; the disease is Sepsis.