To determine if the absence of C1q alters the inflammatory response following B. burgdorferi infection, we measured the levels IL-2, IL-4, IL-10, IL-12p70, IL-17, KC, MCP-1, MIP-1α, TNFα, and VEGF in sera derived from C57BL/6 parent and C1qα−/− mice infected with B. burgdorferi at 7, 10, 21, and 28 days post-infection. The gene discussed is TNF; the disease is infection.