Importantly, Tgαq*44 mice model is characterized by a prolonged course of HF progression with early activation of hypertrophic genes [atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and myosin heavy chain beta (MHC-β)], cardiomyocyte hypertrophy, fibrosis (50, 51), and relatively long-term survival (52). Here, NPPB is linked to hydrops fetalis.