MICA and cytomegalovirus infection: Whereas the analysis of circulating immune effector cells in our opinion would not mirror the situation properly for following reasons: (i) the observed association of CMV infection/disease with the functional MICA gene promotor polymorphism is donor and not recipient specific and (ii) investigation of circulating NKG2D expressing immune effector cells outside the donor tissue and its corresponding microenvironment during CMV infection/disease will not locally mirror the phenotype of infiltrating effectors and their mode of action.