Additionally, Ncf1 colon developed invasive well-differentiated adenocarcinoma in segments where narrower, reserve microglands were visible above the mucularis mucosae, invading till the muscularis propria, accompanied by extensive inflammatory infiltrates harboring lymphocytes expressing high levels of β-catenin (mean scores for total dysplasia WT = 1.71 ± 0.52, Ncf1 = 4.38 ± 0.26, p = 0.001; mean scores for total inflammation WT = 4.14 ± 0.51, Ncf1 = 5.25 ± 0.31, p = 0.03). Here, NCF1 is linked to adenocarcinoma.