In addition to these LoF mutations at candidate CVID genes and interacting proteins, we propose other possible monogenic cases produced by missense variants at CVID candidate genes following a dominant (PRKCD, CLEC16A, DOCK8) or recessive models (CR2, PLCG2), as well as in other genes not previously associated with CVID (KMT2C). Here, CR2 is linked to common variable immunodeficiency.