MSH5 and common variable immunodeficiency: We analyzed the two patients with variants in this gene (Table 1), and searched for variants in genes interacting with TNFRSF13B. Patient L297 harboring the C104R change in homozygosis, also has a heterozygous missense variant with a 2% frequency in TNFRSF13C, which directly interacts with TNFRSF13B. No other variants in interacting proteins were described in the patients with known CVID variants in TNFRSF13B, TNFRSF13C, or MSH5 (Table 1).