We analyzed the two patients with variants in this gene (Table 1), and searched for variants in genes interacting with TNFRSF13B. Patient L297 harboring the C104R change in homozygosis, also has a heterozygous missense variant with a 2% frequency in TNFRSF13C, which directly interacts with TNFRSF13B. No other variants in interacting proteins were described in the patients with known CVID variants in TNFRSF13B, TNFRSF13C, or MSH5 (Table 1). Here, TNFRSF13B is linked to common variable immunodeficiency.