CD4 and infection: In fact, treatment of mice with two neutrophil-depleting antibodies, the GR-1-specific antibody RB6-8C5, which recognizes an epitope shared by Ly6G and Ly6C, and the Ly6G-specific antibody, 1A8, just before infection augments DCs maturation in the skin and the priming of L. major specific CD4+ T cells in vivo, which correlates with faster parasite clearance (Peters et al., 2008; Ribeiro-Gomes et al., 2012).