CD8A and tropical spastic paraparesis: The immunological response elicited by HTLV-1-infected individuals appears to be influenced and modulated by the virus, as its presence may promote the spontaneous proliferation of T CD4+ and T CD8+ lymphocytes and induce the production of proinflammatory cytokines responsible for the symptoms of various diseases, such as HAM/TSP (Goon et al., 2002).