The SNPs on chromosome 13 was not close to any known gene, whereas the SNPs on chromosomes 16 and 4 were either in or near the ZNF423 gene and the CTSO gene encoding CTSO. The alleles for rs8060157 and rs11076499 SNPs on Chr 16 mapped to the intron 2 of ZNF423 and were associated with a decreased risk for BC development with SERM therapy (odds ratio 0.70). This evidence concerns the gene CTSO and breast cancer.