In Epstein–Barr virus infected nasopharyngeal carcinoma, it was found (60) that 8.3% had chimeric fusion rearrangements of Ubiquitin protein ligase E3 Component N-Recognin 5 (UBR5) with the C-terminal domain of ZNF423 (ZF29–30) involved in EBF binding; such chimeric protein increased anchorage-independent growth and tumor formation in nude mice. This evidence concerns the gene ZNF423 and neoplasm.