A methylation analysis of the Zfp423 promoter in obese mice during pregnancy showed a lower H3K27 tri-methylation and higher expression of Zfp423, which predisposes the offspring to obesity, and which was dependent on a reduced binding of enhancer zeste 2 to the Zfp423 promoter (56). Here, ZNF423 is linked to obesity due to melanocortin 4 receptor deficiency.