LEP and Insulin resistance: Although the precise mechanisms are currently still unclear, adipokines and inflammatory factors might play crucial roles in the pathophysiological mechanisms linking adiposity and T2DM; higher concentrations of IL-6, TNF-α, and leptin expression (8, 9), and lower adiponectin levels (10, 11) associated with increased adiposity levels and insulin resistance, might play a pivotal role in our results as they do in T2DM (28).