Moreover, the authors showed that Tregs from the VAT of hyperinsulinemic diet-induced obese mice exhibited a specific decrease in IL-10 production, as well as a parallel increase in IFN-γ production; suggesting that hyperinsulinemia may contribute to the development of obesity-associated inflammation via modulation of Treg function. The gene discussed is IFNG; the disease is obesity due to melanocortin 4 receptor deficiency.