Therefore, T lymphocyte insulin-receptor/GLUTs expression, insulin and glucose levels as well as, the affinity of antigens with cognate TCR of different T cell subsets all have implications to consider for therapeutic manipulation in the setting of hyperglycemia and hyperinsulinemia (T2D) and, during T-cell-mediated T1D featured by elevated glycemia and lack of insufficient insulin levels. Here, INS is linked to type 2 diabetes mellitus.