PLAT and Stroke: The Thrombolysis for Acute Wake-up and unclear-onset Strokes (THAWS) is a multicenter, prospective, open-label trial currently enrolling in Japan that is investigating a lower dose of IV tPA (0.6 mg/kg, which is the approved dose for Japanese stroke patients) in patients with stroke onset 4.5–12 h from LKW and DFM on MRI (120).