PLAT and androgen insensitivity syndrome: WAKE-UP (Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke: A Randomized, Double-blind, Placebo-controlled Trial) is a European multicenter, randomized placebo-controlled, Phase-3 trial using DFM as criterion for IV tPA treatment of AIS patients with > 4.5 h LKW (30).