CLU and Seizure: Our previous study also demonstrated that the expression of zinc transporters ZnT-3, MT-3, and lipid metabolism-related molecules ApoE and clusterin, together with ACAT-1, a mitochondrial enzyme that catalyzes the esterification of cholesterol and long-chain fatty acid to form a cholesterol ester, were downregulated by a ketogenic diet (KD) following neonatal seizures, in parallel with mossy fiber sprouting in hippocampus and deficits of cognition.