CRH and Anorexia: In this regard, Kawaguchi and associates found that exercise-related weight loss in rats was associated with both an increase in arcuate nuclei NPY and corticotropin-releasing factor (CRF) expression in dorsomedial nuclei; intracerebro-ventricular injection of a CRF antagonist attenuated the weight loss, suggesting that CRF was the cause of the exercise-associate anorexia (Kawaguchi et al., 2005).