Dasatinib-induced potassium channel inhibition in pulmonary arterial smooth muscle cells may play a key role in the development of PAH, however, adverse effects on endothelial cells (ECs) cannot be excluded (Nagaraj et al., 2013; Olschewski et al., 2014; Guignabert et al., 2016). This evidence concerns the gene KCNA3 and pulmonary arterial hypertension.