Guignabert et al. (2016) suggested increased ROS production, apoptosis, and elevated expression of endothelial adhesion molecules ICAM-1, VCAM-1, and E-selectin in pulmonary artery ECs as underlying mechanisms. Indeed, increased levels of the adhesion molecules were found in the serum of CML patients (Guignabert et al., 2016). The gene discussed is SELE; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.