Again, C1-INH-HAE is able to dysregulate the activities of complement, coagulation, and contact systems (Kaplan and Joseph, 2014), and increased procoagulant and fibrinolytic activities were observed in HAE patients during attacks and remission phases (van Geffen et al., 2012; Reshef et al., 2015). Here, SERPING1 is linked to hereditary angioedema.