Until recently, some studies have suggested that it exhibits a remarkable anti-oxidative stress (OS)-induced apoptotic effect in HF post-AMI, and CRYAB phosphorylation Ser-59 is selectively responsible for the cytoprotective actions in cardiac myocytes (Kamradt et al., 2001; Morrison et al., 2003; Mao et al., 2004; Taylor and Benjamin, 2005). This evidence concerns the gene CRYAB and hydrops fetalis.