The main findings were as follows: (1) BYD could improve cardiac function, attenuate OS and inhibit apoptosis in HF post-AMI rats; (2) BYD inhibited oxidative stress by decreasing the production of ROS and MDA from cardiac myocytes and LPS-stimulated RAW 264.7 macrophages; (3) BYD protected H9C2 cells against CM-induced apoptosis; (4) In vivo and in vitro studies suggested that the anti-apoptotic effect of BYD was potentially exerted by regulating the P38 MAPK-CRYAB signaling pathway. Here, CRYAB is linked to hydrops fetalis.