SCARB1 and atherosclerosis: Although the action of SR-BI on the removal of cellular cholesterol is less representative than that observed by ABCA-1 and ABCG-1 receptors, its expression seems to play other determinant roles in atherogenesis, since its increased expression protects against development of atherosclerosis in mice, while its deletion induces plaque rupture in hypercholesterolemic animals fed a high fat diet (Vaisman et al., 2015; Hermann et al., 2016).