CYP4F3 and cardiovascular disorder: Among mechanisms to explain the detrimental effects of testosterone on cardiovascular disease, direct actions in the vasculature have been reported such as modulation of cytochrome P-450, cyclooxygenase products, oxidative stress and 20-HETE synthesis (Wu and Schwartzman, 2011; Lopes et al., 2012; Tostes et al., 2015).