In accordance with this research, the important pharmacological mechanisms of LXNX formula to treat CHD disease phenotypes are that the ingredients such as L-arginine and gamma-aminobutyric acid, etc. in Pinellia Tuber, Poria coco, affect CRH in GPCRs signaling pathway and NPPA in specific cellular protein metabolic process. The gene discussed is NPPA; the disease is coronary artery disorder.