NPPA and coronary artery disorder: In summary, CRH and NPPA have strong relationship with LXNX formula for the reasons that they are both the most important drug targets of LXNX formula in LXNX formula’s CHD modules, respectively, co-morbid diseases and symptoms, they are both relevant to the important pathways, respectively, of LXNX formula, and they both can have influence on CHD and CHD co-morbid diseases which LXNX formula can treat.