CaSR are overexpressed in proliferating PASMC from hypoxic rodents or from patients with idiopathic pulmonary hypertension (IPAH), while their pharmacological or genetic suppression reduce proliferation and pulmonary hypertension (Yamamura et al., 2012, 2015; Smith et al., 2016; Tang et al., 2016). The gene discussed is CASR; the disease is pulmonary arterial hypertension.