The TNF-α/TNFR1 signaling could promote GC occurrence by inducing NADPH oxidase organizer 1 (Noxo1) and G protein subunit alpha 14 (GNA14), which are crucial in the tumorigenicity and stemness of GC cells, in tumor cells (Oshima et al., 2014). The gene discussed is GNA14; the disease is gastric cancer.