INS and cancer: Although the mechanisms underlying on cancer prevention and progression are still not fully understood, there is evidence that chronic moderate exercise induce several desirable metabolic alterations, such as reducing fat cell volume (Nechuta et al., 2015; Pistor et al., 2015), improving tissue insulin sensitivity and reducing fasting hyperinsulinemia (Westerlind et al., 2003; Gomes et al., 2013; Keshel and Coker, 2015) and increase pancreatic beta-cell function and mass (Calegari et al., 2012; Gomes et al., 2013; Paula et al., 2018; Veloso et al., 2018).