INS and neoplasm: Although the sedentary rats did not exhibit peripheral resistance to insulin during the tumor growth period in the present study, which has been evidenced in similar cancer models in the literature (Asp et al., 2010; Miksza et al., 2013), we pointed out several aspects in the interpretation of results that should be considered, such as animal species, associated insults, inoculated tissue and volume, experimental time, cellular viability, exercise protocol, drug administration, among others.