STAT3 and brain ischemia: STAT3 activation has been associated with increased neuroinflammation in cerebral ischemia (McGuckin et al., 2013), of which found that the JAK2-STAT3 pathway was involved in the LCN2 induction of CXCL10 secretion and possibly other phenotypic changes associated with reactive astrogliosis (Lee et al., 2011).