Recently, studies have demonstrated that LCN2 is related to a number of CNS injury conditions, such as cerebral ischemia (Jin et al., 2014), excitotoxic injury, stab wound (Chan et al., 2014), medial forebrain bundle transection, and lipopolysaccharide (LPS)-induced neuroinflammation (Suk, 2016). This evidence concerns the gene LCN2 and brain ischemia.