STAT3 activation has been associated with increased neuroinflammation in cerebral ischemia (McGuckin et al., 2013), of which found that the JAK2-STAT3 pathway was involved in the LCN2 induction of CXCL10 secretion and possibly other phenotypic changes associated with reactive astrogliosis (Lee et al., 2011). This evidence concerns the gene CXCL10 and brain ischemia.