The effects of EGB on astrocyte activation, LCN2, p-STAT3, and p-JAK2 expression in the ipsilateral peri-infarct cortical area (-1.7 to -1.9 mm from the bregma) following cerebral ischemia were captured with a laser confocal microscope (Olympus FV1200, Japan). This evidence concerns the gene STAT3 and Cerebral ischemia.