ICAM1 and liver dysplastic nodule: Over-proliferation of GMCs, followed by excessive accumulation of ECM proteins like FN and over-secretion of inflammatory cytokines like ICAM-1, trigger the thickening of GBM and expansion of mesangial area, accelerating the progression of renal fibrosis to develop into DN at last (Kanwar et al., 2011; Kolset et al., 2012).