AKT1 and gastric cancer: Furthermore, miR-129-5p could inhibit the phosphorylation levels of Akt and Erk1/2 in GC cells without obvious changes in the total levels of these proteins, and SLC2A3 knockdown by specific siRNAs suppressed Akt and Erk1/2 phosphorylation (Figure 5D), similar to the effects of miR-129-5p overexpression in GC cells.