We have focused on biological responses to stimulation of exogenously administered BK on neuroblastoma cell lines, such as chemotaxis in response to SDF-1 and ATP, expression and sensitization of CXCR4 and purinergic receptors, ATP-induced pore formation, cell proliferation, adhesion, MMPs activities, VEGF expression and cytoskeleton rearrangement in vitro, as well as induction of neuroblastoma cell dissemination in vivo. This evidence concerns the gene P2RX5 and neuroblastoma.