P2RX6 and neuroblastoma: In our present work, exposure of neuroblastoma cells for 24 h to BK decreased P2X4, P2X5, P2X6, and P2Y2 receptor subtype expression, while expression rates of P2X7, P2Y1, and P2Y12 subtypes in CHP-100 cells were enhanced (Figures 8A,B).