For this, we have studied interactions of factors originated by inflammatory processes and/or leakage of damaged cells, such as adenosine triphosphate (ATP) and bradykinin (BK) (Pinheiro et al., 2013), regarding their priming effects on responsiveness to low concentration of SDF-1 and motility and invasiveness properties of neuroblastoma cells for metastasis formation. The gene discussed is CXCL12; the disease is neuroblastoma.