The URAT1 protein levels in the AAE and AAW treatment groups were 141.50, 128.12, and 143.67 for AAE at various doses and 133.96, 144.49, and 140.17 pg/mL for AAW at different doses, higher than the hyperuricemia control (P < 0.01). The gene discussed is SLC22A12; the disease is hyperuricemia.