Makni-Maalej et al. (2013) have demonstrated that MAPK phosphorylation took part in triggering the activation of NADPH oxidase. But some researchers prove that ROS can mediate the activation of MAPK pathways by a number of cellular stimuli in several cell types (Hsieh et al., 2014; Yu et al., 2014; Youn et al., 2016). Interestingly, Yang et al. (2011) challenge these concepts and reported that, the capsular polysaccharide of pyrogenic liver abscess Klebsiella pneumonia (PLAK. The gene discussed is FMO5; the disease is Klebsiella pneumonia.