It demonstrated that intra-myocardial inflammation in DCM is associated with increased macrophages and leucocytes infiltration, significant increment of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expressions, as well as elevated expression of inflammatory cytokines, including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-18 (IL-18), and transforming growth factor-β1 (TGF-β1) (Tschope et al., 2005; Westermann et al., 2007; Rajesh et al., 2012; You et al., 2018). The gene discussed is IL18; the disease is familial dilated cardiomyopathy.