However, in X. Zhu's research, NUDT15 R139C was not only associated with early leukopenia (0–8weeks) (p = 2.13 × 10−19, OR = 15.67) but also with middle (8–24weeks) and late (>24weeks) leukopenia (p = 4.51 × 10−9, OR = 12.06; p = 0.022, OR = 3.91 respectively) in Chinese IBD patients (Zhu et al., 2016). Here, NUDT15 is linked to Decreased total leukocyte count.