1. A potent cancer chemotherapeutic drug due to its remarkable bioactivity against leukemias and different solid tumors.2. The discovery of bioactivity of camptothecin against DNA topoisomerase I (Topo I) has established great breakthroughs. Accordingly camptothecin was listed on the frontlines of anticancer lead development in the late 1980s (Hsiang et al., 1985).3. Synthesis of analogs and several studies of their pharmacology, formulation, preclinical, and clinical trials were greatly investigated (Ying-Qian et al., 2015). The gene discussed is TOP1; the disease is cancer.