AKT1 and cancer: The signaling cascade that involves phosphoinositide 3-kinase (PI3K), AKT, and mammalian target of rapamycin (mTOR) is the most frequently altered pathway in human cancer and controls many of the processes that play important roles in mediating cancer onset and development (cell survival, mobility, metabolism, the cell cycle, angiogenesis, genomic instability and chemoresistance) (Fruman and Rommel, 2014).