Therefore, disturbances of brain glucose uptake, glucose tolerance and glucose utilization and impairment of the insulin/IR signaling cascade are thought to be key targets for the neuropathology of the sporadic form of AD (sAD) which covers >95% of AD patients (Grünblatt et al., 2007; de la Monte, 2009; Salkovic-Petrisic et al., 2009; Talbot et al., 2012). This evidence concerns the gene INSR and Alzheimer disease.