APP and Alzheimer disease: While the role of the activated microglia could be neuroprotective, the strong microglial activation in APP models could also drive the AD pathology (Maphis et al., 2015; Olmos-Alonso et al., 2016; Spangenberg et al., 2016) and, in consequence, it could be implicated in the neurodegenerative process observed in APP-models.