On the other hand, missense mutations in TREM2 (such as R47H TREM2) produce an increases risk for late-onset AD (Guerreiro et al., 2013; Korvatska et al., 2015; Yeh et al., 2016) and a reduction in the number of microglial cells surrounding Aβ plaques in models. The gene discussed is TREM2; the disease is Alzheimer disease.