It has been shown that several AD-like mouse models with hyperphosphorylated tau and/or increased GFAP levels had significantly higher levels of Ccl4 (one of inflammatory markers, also known as MIP-1β; Dong et al., 2007; Javidnia et al., 2017), which might be a potential cerebrospinal fluid biomarker of AD (Trombetta et al., 2018). This evidence concerns the gene GFAP and Alzheimer disease.