In conclusion, the present study suggested the selectively neuroprotective role of low sOBR level and high plasma leptin level, which may be a good predictor of MCI (Zeki Al Hazzouri et al., 2013) especially in diabetic women and provided insight that WHR (visceral obesity) may contribute to the development of cognitive impairment in patients with T2DM. The gene discussed is LEP; the disease is type 2 diabetes mellitus.