Besides, the promotion of inflammation, insulin resistance, reduced adiponectin which is also associated with MCI (Kamogawa et al., 2010; Diniz et al., 2012), and leptin resistance et al. induced by increased visceral fat may also contribute to cognitive deficient (Doumatey et al., 2010; Luchsinger et al., 2012). Here, LEP is linked to Insulin resistance.