EGR3 and schizophrenia: Bioinformatics approaches have identified Egr3 as a central gene in a network of transcription factors and microRNAs implicated in schizophrenia risk (Guo et al., 2010), as well as a master regulator of genes differentially expressed in the brains of bipolar disorder patients in two independent cohorts (Pfaffenseller et al., 2016).