We have hypothesized that dysfunction of Egr3 could disrupt the brain’s normal neurobiological response to stress, resulting in increased risk to develop mental illnesses such as schizophrenia and bipolar disorder (Gallitano-Mendel et al., 2007, 2008; Williams et al., 2012; Huentelman et al., 2015; Pfaffenseller et al., 2016; Marballi and Gallitano, 2018). This evidence concerns the gene EGR3 and psychiatric disorder.