Intravenous treatment of rats with URB937, a FAAH inhibitor with minimal penetration of the CNS decreased activity of bladder-specific afferent nerve in response to controlled filling of the bladder (Aizawa et al., 2014), and similar results were obtained by administration of URB937 prior to induction of cystitis by intravesical instillation of prostaglandin E2 (Aizawa et al., 2016). Here, FAAH is linked to cystitis.