Given that the Cdk5/p35 complex has been implicated in a variety of disorders, including epilepsy (Wenzel et al., 2001; Putkonen et al., 2011) and AD (Lew et al., 1994; Patrick et al., 1999; Yoo and Lubec, 2001), these findings are helpful in deciphering the purpose of the continued expression of these proteins in postnatal neurons. The gene discussed is CDK5; the disease is Alzheimer disease.